The Tigers scored four runs in the eighth off White Sox reliever Matt Purke to increase their lead to 10-2.
Purke walked three batters — included a bases-loaded walk to Andrew Romine — and gave up three hits.
Ian Kinsler, Victor Martinez (groundout) and J.D. Martinez also had an RBI apiece during the inning.
James McCann's hot night continued with a leadoff triple, his first on the year. McCann is 3-for-4 with a solo homer and two RBIs tonight.
Victor Martinez is 3-for-5 with two RBIs and J.D. Martinez is 2-for-4.
Detroit has 14 hits tonight.