In what was easily his best start of the season, right-handed pitcher Anibal Sanchez struck out a season-high eight hitters for the Tigers.
Sanchez allowed two runs on five hits and no walks over six innings.
The Tigers beat the Giants, 6-2, in front of an announced crowd of 27,210 on Thursday at Comerica Park.
Sanchez has struck out at least five hitters in three of his four starts this season for the Tigers. He improved to 4-1 in six career starts against the Giants.
Alex Presley went 2-for-2 with a walk, two RBI and a run scored for the Tigers.