The NFL opens up Week 3 with a matchup between the New York Giants and San Francisco 49ers on “Thursday Night Football.”
These two teams have faced off against each other 42 times and are dead even in wins and losses: each team has won 17 regular season games and four post-season games against each other. In recent history, the 49ers have won two of the last three meetings, including a 36-9 victory the last time they battled, back in 2020.
This game could come down to which team can best execute in the run game. The 49ers have one of the best rushing attacks in the NFL and average 173.