The San Francisco 49ers and Seattle Seahawks will kick off Week 6 on “Thursday Night Football” in a battle between NFC West rivals. Recent history favors San Francisco in this series, as the 49ers hold a 29-21 edge in regular season matchups, including winning the last four.
The 49ers are 2-3 on the season, with wins over the Jets and Patriots, and losses to the Vikings, Rams, and Cardinals. A combination of bad luck with injuries and facing two familiar NFC West rivals has put the 49ers in an early season hole. Meanwhile, the Seahawks hold a 3-2 record, with wins over the Broncos, Patriots, and Dolphins to start the season, but lost to the Lions in Week 4, then fell victim to the “Lions Hangover” and lost to the Giants last week.