On the Titans' first drive of the second half, safety Glover Quin came up with a turnover as he intercepted Marcus Mariota's pass down the right sideline at the Detroit 28.
The Lions turned that turnover into three points as Matt Prater connected on a 27-yard field goal to cap a 14-play, 63 yard drive to extend Detroit's lead to 15-3 with 1:40 left in the third quarter.
With Ameer Abdullah out, rookie Dwayne Washington got some extended reps and got the drive off to a promising start, converting a first-and-20 with a 28-yard run after Laken Tomlinson was called for another holding penalty.