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Jared Goff, D’Andre Swift and several projected starters are slated to sit after the teams held joint practices the days prior.
In their preseason opener, the Lions lost a nail-biter to the Atlanta Falcons.
More:Detroit Lions vs. Indianapolis Colts: Here are the 5 players to watch in preseason game
The Colts lost, 27-24, to the Buffalo Bills to open the preseason.
Preseason: Detroit Lions (0-1) vs. Indianapolis Colts (0-1)
When: 1 p.