The Detroit Lions will be without u2156 of their starting offensive line for Thursday's Thanksgiving game against the Buffalo Bills.
The Lions ruled guards Jonah Jackson and Evan Brown out with injuries. Brown sprained his ankle in last week's win over the New York Giants, while Jackson appeared on the practice report Tuesday with a brain injury.
Cornerback Jeff Okudah (concussion) and defensive linemen Charles Harris (groin) and Josh Paschal (knee) also are out, while receiver Josh Reynolds (back) is questionable.
The Lions (4-6) will start their fifth different grouping on the offensive line this season against a Bills team expected by many to challenge for the Super Bowl.