Game of the week
San Francisco (plus 4 1/2) at L.A. Rams
Huge measuring stick game for both teams. Are the 49ers (4-0) for real? Are the Rams (3-2) in legitimate trouble? Yes and almost. San Francisco looked like a well-oiled machine in its throttling of Cleveland on Monday, but the Rams rebound.
Rams 27, 49ers 23
Lock of the week
Philadelphia (plus 3) at Minnesota
It appears their come-from-behind win at Green Bay in Week 4 was what the Eagles needed to get hot.