Broncos quarterback Trevor Siemian went down with a left shoulder injury in the final minute of the first half and was quickly replaced by Brock Osweiler. Siemian was listed as questionable to return, and did in the second half.
Tackle Menelik Watson was injured on the play before the interception and was ruled out for the second half because of a calf injury.
Siemian landed hard trying to make a tackle after throwing his second interception of the night, which was returned for a touchdown by Janoris Jenkins.
The second-year quarterback suffered an AC joint sprain in his left shoulder in Week 4 of last season, and after playing the remainder of the year in pain, underwent surgery in January.