Jaguars star cornerback Jalen Ramsey is inactive for the first time in his four-year NFL career.
Ramsey, who asked for a trade two weeks ago, flew with the Jaguars to Denver after missing practice all week because of illness, a back injury and the birth of his second child back in Nashville.
Ramsey will be replaced at left cornerback second-year pro Tre Herndon.
The Broncos are without three of their big free agent signings with cornerback DB Kareem Jackson (hamstring) joining sidelined cornerback Bryce Callahan, who underwent a procedure on his left foot last week and will be out for at least a month, and right tackle Ju’Waun James, who hurt his left knee in the opener.