Broncos coach Gary Kubiak announced Friday cornerback Kayvon Webster (ankle) is doubtful to play Sunday against Detroit.
The coach also said defensive end Kenny Anunike (knee) and safety Omar Bolden (foot) are questionable, and guard Louis Vasquez (knee) is listed as probable.
Kubiak considers Anunike and Bolden to be game-time decisions.
All four players practiced on a limited basis Friday, and running C.J. Anderson (toe) has practiced full all week.
The rest of the team, Kubiak said, will be good to go.
"We haven't had this problem in a few weeks where everybody is kind of healthy," Kubiak said.