The Denver Broncos will need a lot of reserve players to step it up on both offense and defense as they lose several key starters headlined by Emmanuel Sanders and Chris Harris Jr. Sanders is done for the year, but Harris might be ready to return by the playoffs.
Inactive for this game will be cornerbacks Tramaine Brock and Chris Harris Jr, outside linebackers Jeff Holland and Shaquil Barrett, inside linebacker Brandon Marshall, defensive end DeMarcus Walker, and guard Nico Falah.
For the San Francisco 49ers, they will have inactive in this game wide receiver Pierre Garcon, running back Matt Breida, cornerback K’Waun Williams, safety Jaquiski Tartt, defensive lineman Sheldon Day, and offensive linemen Erik Magnuson and Shon Coleman.