The Denver Broncos travel to Santa Clara, California to take on the San Francisco 49ers. It marks the first meeting between the two teams in the regular season since 2014. In that game, we saw Peyton Manning pass Brett Farve for most touchdown passes in a career. It was a dominate performance by the Broncos.
Fast forward four years later, and the teams have dealt with major changed. Peyton Manning and Colin Kaepernick are no longer the quarterbacks for the Broncos and 49ers respectfully. The Broncos will see Nick Mullens and the 49ers will see Case Keenum.
As far as the 2018 season goes, both teams are in opposite directions.