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UPDATED: December 1, 2024 at 9:05 PM MST
ORCHARD PARK, N.Y. (AP) — San Francisco 49ers running back Christian McCaffrey suffered a knee injury and limped to the locker room in the second quarter against the Buffalo Bills on Sunday night.
The Niners announced at the start of the third quarter that he would not return.
McCaffrey stepped awkwardly on a sweep to the left on a snow-slicked field. The All-Pro went down almost immediately for a 5-yard loss. He went to the sideline and was examined in the medical tent before exiting the field.