The circumstances favor Queretaro, but United could still get a good result today if they keep their heads and avoid mistakes.
For the second straight year, D.C. United has landed what is relatively speaking a favorable CONCACAF Champions League quarterfinal pairing. Queretaro is stumbling through the Liga MX season right now, picking up their only wins against the league's worst two teams. They struggle to create attacking opportunities, and are far more direct than Liga MX's reputation would indicate.
Nonetheless, the Mexican side will be favored because they're in season, they're at home - with a significant boost thanks to the altitude - and they've spent far more than United to assemble their squad.