Eberechi Eze scored twice in the second half to ease pressure on Crystal Palace - and double down on Southampton's misery.
After a goalless first half at St. Mary's, Eze scored in the 54th and 68th minutes to send the Eagles nine points clear of the Premier League's drop zone.
Meanwhile, the Saints fell to another defeat, with games running out in the bottom club's race to avoid relegation to the Championship.
More to follow...
Eberechi Eze scored a second half double to ease Crystal Palace's fears of relegation this term
Bottom club Southampton are running out of matches to get themselves out of danger
MATCH RATINGS
Southampton (4-4-2): Bazunu, Maitland-Niles, Bednarek, Bella-Kotchap, Walker-Peters, Walcott (Djenepo 62'), Ward-Prowse, Lavia, Sulemana (Armstrong 80'), Alcaraz (Edozie 80'), Aribo (Onuachu 62')
Booked: Lavia, Bednarek, Bella-Kotchap
Manager: Ruben Selles
Crystal Palace (4-3-3): Johnstone, Ward, Andersen, Guehi (Tomkins 90+3'), Mitchell, Eze, Doucoure (Milivojevic 85'), Schlupp (Sambi Lokonga 85'), Olise, Edouard (Hughes 74'), Ayew (Mateta 90+3')
Goals: Eze 54, 68
Booked: Andersen
Manager: Roy Hodgson