Injury-hit Sheffield United may be forced to call upon new arrivals Auston Trusty, Benie Traore and Vinicius Souza - the latter only joined on Thursday.
Jayden Bogle, Rhian Brewster and John Fleck are among those injured, while Oli McBurnie and Daniel Jebbison are unlikely to recover from respective ankle and groin issues in time to play.
Crystal Palace will hand ex-Bournemouth midfielder Jefferson Lerma his debut.
Michael Olise has a hamstring injury while Matheus Franca is also out.
Manager Roy Hodgson has said unsettled goalkeeper Vicente Guaita refused to play during pre-season. Sam Johnstone is instead likely to start.