Crystal Palace forward Eberechi Eze and midfielder Adam Wharton are both set to be out for a month with their injuries, says manager Oliver Glasner.
Both players went off during the Eagles' midweek Carabao Cup last-16 win against Aston Villa.
Wharton is to undergo surgery for a groin issue while forward Eberechi Eze is out with a hamstring injury.
"It will be very ambitious to have [Eze] back after the [mid-November] international break, but I know we have a great medical department and he will work quite hard, so let's see," said Glasner.