Manchester United could give a debut to loan signing Marcel Sabitzer, who has been brought in to replace the injured Christian Eriksen.
Right-back Diogo Dalot is back in training, while Anthony Martial and Jadon Sancho might start after making their return from the bench in midweek.
Crystal Palace top scorer Wilfried Zaha faces time on the sidelines after suffering a hamstring injury.
New signings Naouirou Ahamada and Albert Sambi Lokonga might feature.
CHRIS SUTTON'S PREDICTION
Crystal Palace nicked a draw right at the end of the game when these two teams met at Selhurst Park last month - it cost me some prediction points too because I had gone for a 1-0 Manchester United win.