Manchester United goalkeeper Joel Pereira is expected to be given his Premier League debut on Sunday.
Demi Mitchell, Angel Gomes, Josh Harrop and Scott McTominay could make their senior bows, while Paul Pogba and Timothy Fosu-Mensah will play.
Marouane Fellaini and Chris Smalling have minor injuries and may be rested ahead of the Europa League final.
James Tomkins should be fit for Crystal Palace after an ankle problem but Yohan Cabaye is a doubt due to a foot injury.
Andros Townsend will miss the game because of an Achilles injury.
MOTD COMMENTATOR'S NOTES
Steve Bower: "So it's the game Jose Mourinho didn't want, on the day he didn't want; the week ahead will determine if it turns out to be the season he didn't want, with events in Stockholm on Wednesday determining whether he has restored the Champions League nights for Manchester United.