Manchester United are weighing up whether to hand summer signing Donny van de Beek his competitive debut.
Paul Pogba and Mason Greenwood are available after completing coronavirus quarantines.
Crystal Palace's lengthy injury list includes Gary Cahill, James Tomkins and Patrick van Aanholt.
Mamadou Sakho returned in the EFL Cup in midweek and may feature, while Christian Benteke, Connor Wickham and Jairo Riedewald are being assessed.
LAWRO'S PREDICTION
This is Manchester United's first game back, while Crystal Palace started well with a good win over Southampton.
With Michy Batshuayi, on loan from Chelsea, the Eagles look like they have a few avenues for goals, which has been a problem for them in the past.