Crystal Palace will monitor defenders Mamadou Sakho, James Tomkins and Gary Cahill, all of whom are recovering from injuries.
Manchester City defender John Stones serves the second game of a three-match domestic ban, with Aymeric Laporte set to replace him.
Ilkay Gundogan was hurt by a heavy tackle in midweek but should be fit.
Squad rotation is likely to see Raheem Sterling, Gabriel Jesus and Ferran Torres return to the starting line-up for City, who will be crowned champions if they win at Selhurst Park and Manchester United lose to Liverpool a day later.