Crystal Palace midfielders Michael Olise and James McArthur are out with respective foot and groin injuries.
Arsenal are likely to be without midfielder Emile Smith Rowe, who is struggling with a groin issue.
Kieran Tierney, Takehiro Tomiyasu and Fabio Vieira are all recovering from injuries, with Mikel Arteta admitting that "most of them" will be available.
French defender William Saliba is in line for a first start in an Arsenal shirt, while former Manchester City players Gabriel Jesus and Oleksandr Zinchenko should also make their debuts.
MATCH FACTS
Head-to-head
- Crystal Palace have lost one of their past eight Premier League meetings with Arsenal (W2, D5).