Bobby Decordova-Reid, Tim Ream and Aleksandar Mitrovic gave Fulham a winning return to Premier League action after the World Cup, after Crystal Palace were reduced to nine men.
Decordova-Reid gave the visitors the lead by heading in from a Mitrovic cross on the half hour mark, before Tyrick Mitchell was shown a straight red card for a dangerous lunge on Kenny Tete.
Palace were dealt another blow in the second half after being reduced to nine men, with James Tomkins shown a second yellow card.
Ream doubled the visitors' lead with the defender bundling home from inside the box, before Mitrovic struck late on.