Goalkeeper Edouard Mendy and left-back Ben Chilwell could make their league debuts for Chelsea after featuring in the Carabao Cup game at Tottenham.
Striker Timo Werner should be fit despite suffering from cramp in the latter stages of Tuesday's match.
Crystal Palace are without striker Michy Batshuayi, who is ineligible against his parent club.
Jeffrey Schlupp is a doubt after missing last weekend's game against Everton with a muscle strain.
MATCH FACTS
Head-to-head
- Chelsea have won five successive matches against Crystal Palace.