Melancon was pulled in favor of Jared Hughes, and Cristhian Adames hit his first Major League home run to give the Rockies a four-run lead.
The Rockies took a 1-0 lead in the first on Mark Reynolds' RBI double, and the Pirates tied it in the fourth on Jordy Mercer's RBI single, scoring Matt Joyce. Joyce collided with Wolters at home, but scored.
A few plays earlier in the fourth, Pirates third baseman Jung Ho Kang also collided with Wolters at the plate, but was called out.