Pregame:
- The Colorado Buffaloes will kickoff the 2021 season at Folsom Field against in state foe Northern Colorado.
- Colorado leads the overall series between the two schools 10-2 after being victorious in their most recent meeting in 2017 where the they won 41-21.
- The Buffaloes are fresh off their first winning season since 2016 in a shortened 2020 campaign due to the COVID-19 pandemic (Colorado finished 4-2, 3-1 Pac-12). The last time the herd took the field was in the Alamo Bowl where they fell to Texas 55-23.
- Northern Colorado has not competed in a game in 650 days after opting out for the entire season last year.