Santana made it a 2-0 game in the fourth inning with his first two-run homer of the night, a shot to right field on a 1-0 pitch from Reds starter Tim Adleman. Four batters later, Adleman departed with a strained left oblique. Cleveland had one out and one run in during the fifth against reliever Caleb Cotham when Santana jumped on a first pitch for his second two-run homer to right field.
Indians starter Josh Tomlin improved his record to 6-0 as he pitched 7 2/3 innings and gave up two earned runs, five hits and one walk with seven strikeouts.