"You get a chance against him, you better take advantage of it," Indians manager Terry Francona said. "Because, a lot of times, that's the only one you get."
Cleveland took complete advantage and kept its foot on the gas all night.
Santana crushed an 0-1 pitch from Sale over the wall in left field and to the bleacher seats for a grand slam that punctuated a six-run outburst in the third inning -- all of them unearned after a Chicago error.