Will Brennan made his major league debut September 21st, 2022. His first game was against a Chicago White Sox team that was starting, what has since become, a multi-year crumble. In the top of the 3rd inning in his 2nd big league plate appearance he hit a single on a sinker from RHP Lance Lynn right over the plate for his first hit and first RBI. Brennan ended the night going 2-for-4 with an RBI.
Brennan started the 2022 season in AA Akron, getting the promotion to AAA Columbus Clippers early in the season on May 26th, 2022.