The Browns placed Bowie on the reserve/retired list Friday and signed undrafted rookie defensive lineman Kenton Adeyemi.
The Browns claimed Bowie, 24, off waivers from the Seattle Seahawks in August 2014, but he never appeared in a regular-season game with Cleveland. He spent each of the past two seasons on injured reserve with shoulder injuries.
As a rookie seventh-round draft pick in 2013, Bowie started eight of his nine games with the Seahawks.
Adeyemi, 6-foot-3 and 279 pounds, entered the NFL in May when he signed with the Chicago Bears, who waived him in June. Adeyemi started 23 of the 30 games in which he appeared at the University of Connecticut and compiled 63 tackles and three sacks.