The full injury and practice report for Cleveland vs. San Francisco is below.
| BROWNS | WED | THU | FRI | STATUS |
| WR Andrew Hawkins (concussion) | DNP | DNP | DNP | OUT |
| CB Joe Haden (concussion) | DNP | DNP | DNP | OUT |
| CB Justin Gilbert (concussion) | DNP | DNP | DNP | OUT |
| WR Travis Benjamin (shoulder) | DNP | LP | LP | QUESTIONABLE |
| WR Taylor Gabriel (concussion) | DNP | LP | LP | QUESTIONABLE |
| WR Brian Hartline (hip) | LP | LP | LP | QUESTIONABLE |
| WR Marlon Moore (ribs) | LP | LP | LP | QUESTIONABLE |
| TE Gary Barnidge (ankle) | LP | LP | LP | QUESTIONABLE |
| QB Johnny Manziel (right elbow) | FP | FP | FP | PROBABLE |
| OL Cameron Erving (ankle) | LP | FP | FP | PROBABLE |
| 49ERS | WED | THU | FRI | STATUS |
| RB Carlos Hyde (foot) | DNP | DNP | DNP | OUT |
| TE Vance McDonald (concussion) | DNP | DNP | DNP | OUT |
| LB Michael Wilhoite (ankle) | DNP | DNP | DNP | OUT |
| WR Torrey Smith (back/toe) | FP | DNP | LP | QUESTIONABLE |
| LB Aaron Lynch (concussion) | DNP | DNP | LP | QUESTIONABLE |
| CB Tramaine Brock (foot) | FP | FP | LP | QUESTIONABLE |
| RB Kendall Gaskins (hamstring) | FP | FP | FP | PROBABLE |
| WR Anquan Boldin (hamstring) | FP | FP | FP | PROBABLE |
| OT Joe Staley (knee) | DNP | LP | FP | PROBABLE |
| OG Alex Boone (knee) | LP | LP | FP | PROBABLE |
| OG Andrew Tiller (knee) | LP | LP | FP | PROBABLE |
| OT Erik Pears (knee) | FP | FP | FP | PROBABLE |
| C Marcus Martin (ankle) | LP | LP | FP | PROBABLE |
| DT Arik Armstead (shoulder) | FP | FP | FP | PROBABLE |
| DT Quinton Dial (shoulder) | LP | LP | FP | PROBABLE |
| DT Mike Purcell (shoulder) | FP | FP | FP | PROBABLE |
| LB NaVorro Bowman (shoulder/finger) | DNP | FP | FP | PROBABLE |
| LB Eli Harold (shoulder) | LP | LP | LP | PROBABLE |
| S Jaquiski Tartt (ankle) | FP | FP | FP | PROBABLE |