Clemson came into the eighth inning on Sunday nursing a one-run lead on No. 10 Florida State in the rubber match of their three-game series.
But, like they did in Game 1, the Seminoles scored four runs in the bottom of the eighth inning to down the Tigers 9-6 at Howser Stadium in Tallahassee, Fla.
With the loss the Tigers fell into a tie for 10th in the ACC standings.
The Tigers (24-23, 16-17 ACC) are tied with Virginia for 10th place, who won the series at Clemson last month. Clemson will likely need to win the series over Duke next week to be in position to make the NCAA Tournament.