Between 1800 and 1830, most Native American tribes in the U.S. South succumbed to the pressure of white encroachment onto Indian lands, as well as economic and political manipulation designed to promote the acquisition of Indian land by white Americans. Indian wars played a crucial role in shaping the early United States, from the two Cherokee Wars (1758-1761 & 1776-1777 in the Appalachians) and Pontiac's Rebellion (1763 in the Ohio River Valley) during the Revolutionary Era to Tecumseh's Rebellion (1811-1813 also in the Ohio Valley) and the Red Stick War (1813-1814 in Georgia and Alabama). But this incessant violence, along with the negative long term effects of European diseases on Indian populations, combined to limit Native Americans' ability to resist white expansion in the early antebellum era.