Clemson is unbeaten on the season at 6-0 but only 1-3 against the spread over its last four games, seemingly favored by a few points too many too often. The Tigers will go off as favorites on the road when they meet Miami for an ACC interdivisional bout Saturday afternoon at Sun Life Stadium.
Point spread: Tigers opened as 3.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 24.5-20.3 Tigers
Why the Clemson Tigers can cover the spread
Clemson now owns a nine-game winning streak after beating Boston College last week 34-17.