The Louisville Cardinals are off to an 0-2 start to the 2015 season both straight up and against the spread, and they're also just 3-2 SU and 0-5 ATS in their last five home games. Meanwhile, Clemson owns a four-game winning streak both SU and versus the numbers. In what's already a key game in the ACC Atlantic Division Louisville tangles with the Tigers Thursday night at Papa John's Stadium.
Point spread: This game opened as a pick 'em, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 22.