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Clemson schedule thoughts: November once again features critical five-game stretch

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November will once again tell the tale.

Clemson’s 2025 football schedule was finally released by the Atlantic Coast Conference Monday night, and there was one huge surprise: The Tigers will once again play on Friday night this season, traveling to Louisville (where you can bet it will be raining) to take on the Cardinals on a night usually reserved for high school football.

Clemson last played at Louisville in 2021 and is 4-0 there, but the Cardinals are coming off their first win in the series last fall, 33-21.

Clemson is 32-25-5 all-time in games played on Friday.