The Clemson football team will travel up to Louisville to take on the Cardinals.
The Tigers will look to remain undefeated on the season and improve to 7-0 here in the midst of an October run. Clemson is currently ranked No. 3 in the nation and the Tigers will be looking to make some statements throughout the month of October before the CFB Playoff committee comes out with its first poll.
Here is our pick against the spread for Clemson football heading into the matchup with Louisville. All of our spreads are courtesy of the Action Network.