Twelve players who were on the Reds 25-man Opening Day 2015 roster are no longer with the organization:
- C: Brayan Peña
- IF: Kristopher Negron, Chris Dominguez
- OF: Brennan Boesch, Marlon Byrd, Skip Schumaker
- SP: Johnny Cueto, Mike Leake, Jason Marquis
- RP: Burke Badenhop, Kevin Gregg, Manny Parra
Five players who were chosen for the Opening Day roster appeared in few games for the Reds – all had been sent to the minors or released by mid-June:
- Brennan Boesch (51)
- Kristopher Negron (43)
- Chris Dominguez (14)
- Jason Marquis (10)
- Kevin Gregg (11)
Nine other players are no longer with the organization or cut from the 40-man roster:
- OF: Jason Bourgeois, Ryan LaMarre
- P: David Holmberg, Pedro Villarreal, Sam LeCure, Collin Balestar, Sean Marshall, Josh Smith, Nate Adcock, Ryan Mattheus
The released relief pitchers made 267 appearances last year.