There were certainly higher profile departures offthe 2020 Cincinnati Reds roster than Michael Lorenzen, even though he’s consistently been a valuable member of the club. That said, I’m not sure there were departures that created as many holes - plural - as has Lorenzen’s serious shoulder injury.
The plan was to see him depart the bullpen for a starting spot, though that plan never really replaced his spot in the bullpen with anything proven in much the same way the voids of Raisel Iglesias and Archie Bradley were never replaced. If Lorenzen could become a viable starter, though, that would have gone a long way to assuage the departures of both Trevor Bauer and Anthony DeSclafani, but the injury derailed that plan altogether.