Editor's note: All odds are via the Barstool Sportsbook (available at the Hollywood Casino in Lawrenceburg, Indiana) since it's the closest to Cincinnati. Picks provided here are only for fun and not meant to be gambling advice. If you, or someone you know, have a gambling problem, call 1-800-GAMBLER.
The Cincinnati Reds and St. Louis Cardinals begin the 2021 Major League Baseball season at 4:10 p.m. at Great American Ball Park. Opening Day will see Reds right-hander Luis Castillo face Cardinal's righty Jack Flaherty.
While the Reds are slightly favored (-122) over the Cardinals (-104), the Cardinals are the favorites to win the National League Central Division (+133) while the Reds have the second-best odds (+322).