Peyton and Eli Manning both won Super Bowls playing quarterback but never faced each other in the big game.
Just 10 years ago, Jim and John Harbaugh squared off as opposing head coaches when the Baltimore Ravens beat the San Francisco 49ers in Super Bowl 47.
However, no two brothers have ever suited up against one another in a Super Bowl.
Come Feb. 12, Ed and Donna Kelce's sons will make NFL history as Jason's NFC champion Philadelphia Eagles will clash with Travis Kelce's AFC champion Kansas City Chiefs in Super Bowl 57.