The White Sox struck first in the top of the second inning with Bryan Ramos grounding out, second baseman Andrés Giménez to first baseman Josh Naylor. Nicky Lopez doubles on a sharp line drive to right fielder Will Brennan of the Guardians. Paul DeJong scores placing White Sox in the lead 1–0.
Martín Maldonado singled on a ground ball to left fielder Estevan Florial of the Guardians. Nicky Lopez scores placing the White Sox 2–0.
In the top of the fourth inning, Josh Naylor from the Guardian hits a home run on a fly ball to left field placing them at 2–1 against the White Sox.