Yankees opener Chad Green struck out Leury Garcia to begin the bottom of the first.
It was the first of 16 strikeouts by Sox hitters in an 8-4 loss to the Yankees in front of a sellout crowd of 36,074 Saturday at Guaranteed Rate Field.
Eloy Jimenez and Jose Abreu each had two hits, and James McCann hit a three-run homer in the loss.
Every batter in the Sox starting lineup struck out at least once. McCann and Welington Castillo struck out three times.