Tim Anderson hit a two-run homer in the 12th inning, and the White Sox beat the Kansas City Royals 4-2 on Wednesday night.
Anderson's blast off Burch Smith (1-5), the sixth Royals pitcher, landed just beyond the fence in left-center.
Juan Minaya (2-2) pitched two scoreless innings for the win. Hector Santiago, the eighth Chicago pitcher, picked up his second save in as many chances.
Jose Rondon also homered for the White Sox, who snapped a seven-game skid, one game short of their season-worst losing streak.