Coming into 2021, the White Sox had what was generally considered a middle-tier farm system. There was exceptional talent at the top that could match most any other franchise, but a very steep drop after which was going to require a lot of actual development and results from the second tier.
Now that Andrew Vaughn, Michael Kopech, Nick Madrigal, and Garrett Crochet have all graduated from prospect status (and, in the case of Madrigal, been traded), we are left with something of a barren wasteland.
As of now, the White Sox are arguably the only team that does not have a single prospect with Top 100 status, and it might not be a stretch to say none of their prospects even enter Top 150 status.