Red Sox struck first with a home run by Wilyer Abreu to right field in the bottom of the second inning.
Elvis Andrus gave the White Sox the lead in the top of the fifth with a double to left field on a deflected catch by Red Sox center fielder Ceddanne Rafaela that scored Gavin Sheets and Korey Lee.
White Sox would extend their lead in sixth on a Gavin Sheets sacrifice fly to bring home Eloy Jiménez.
Adam Duvall would shorten the lead by one on a solo homer to center field.
The game would enter a rain delay and eventually be called in six innings due to weather in Boston.