Yoan Moncada returns to Fenway Park on Friday night as the White Sox open a three-game series against the Red Sox.
Former White Sox ace Chris Sale will face his former team, having been sent to Boston in the 2016 deal that brought Moncada and Michael Kopech to the South Side.
Sale has lost his last two starts against the Braves and Astros but ranks second in the American League with 110 strikeouts.
He faced the White Sox once last year, notching the win May 17 in Chicago despite allowing six runs on 10 hits and two walks in five innings.