Giolito allowed four runs on seven hits with nine strikeouts in seven innings. Tigers starter Tarik Skubal allowed one run on four hits with 11 strikeouts and three walks in five innings.
Eric Haase homered twice against Giolito and Miguel Cabrera hit the 492nd home run of his career as the Tigers handed the Sox just their third loss in the last 10 games.
Haase hit a two-run homer in the second and a solo home run in the fourth, giving the Tigers a 3-1 lead. Cabrera’s solo homer in the sixth made it 4-1.
The Sox got within one run in the sixth with a two-run double by Jake Lamb against reliever Derek Holland.