Albert Almora Jr. will lead off Friday when the Cubs travel to Camelback Ranch in Glendale, Ariz., to face the White Sox.
Almora went 0-for-3 from the ninth spot Thursday in a 2-1 win over the Rangers and is batting .286 in spring training.
David Bote will start at shortstop as the Cubs explore their infield options. Christhian Adames is at third base and Ian Happ at second.
The Cubs will send left-hander Cole Hamels to the mound against Sox right-hander Lucas Giolito.